Endocrine Abstracts

IntroductionAcromegaly is a chronic, slowly progressing disease caused in most cases by growth hormone (GH)- producing pituitary neuroendocrine tumors (PitNETs). This rare disorder is associated with a spectrum of various clinical manifestations and treatment outcomes differ between patients. The aim of this study was to evaluate the impact of age at the onset of symptoms and sex on clinical features, comorbidities, biochemical status at the diagnosis, a...

BackgroundSilent somatotroph pituitary tumours are very rare, representing only 2-4% of all pituitary tumours in surgical series. Little is known about the course of the disease and efficacy of possible treatment modalities.Presentation of the caseA male, born in 1990, was first admitted to the hospital at the age of 15, due to sudden ptosis of the right eye and headaches, present for 1 year before the diagno...

BackgroundMultiple neuroendocrine neoplasia type 1 is a rare, heterogeneous genetic disorder with an autosomal dominant inheritance, predisposing to benign and malignant tumors. The phenotype of MEN1 syndrome varies between patients in terms of tumor localisation, age of onset and clinical aggressiveness, even between affected members of the same family. We report a heterogenic phenotype of the MEN1 variant c.[781C > T] (LRG_509t1) previously reporte...